What is peptide Impurities?

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What is peptide Impurities?
By Somabiotech Co., Ltd

 Most of our customers often ask what other substances (impurities) are present in their peptide samples. This depends significantly on whether or not the sample was purified by reverse-phase HPLC. The following table summarizes the difference between the two cases.

 Impurities found in Non-Purified Peptides 
Deletion sequences
Truncation sequences
Incompletely deprotected sequences
Sequences modified during cleavage (reattachment of protecting groups at other locations on the peptide)
DTT (dithiothreitol)
TFA (trifluoroacetic acid)
Acetic acid
Peptides that have undergone side reactions such as proline isomerization or isoaspartimide formation, etc.

 (Note that the impurities are both peptides and non-peptides.)

 Impurities found in Purified Peptides

 Deletion sequences
Truncation sequences
Incompletely deprotected sequences
Sequences modified during cleavage (reattachment of protecting groups at other locations on the peptide)
Racemic impurities of amino acids

 (Note that the impurities are mostly peptides with modified sequences, except for TFA salt.)

TFA is removed except the HGH fragment for all our products.


Contact Amanda
Email: amanda@somabiotech.com
WhatsApp: +8615918445525
Twitter: https://twitter.com/AmandaLee2829

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